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In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. <t>(C)</t> <t>SPECT/CT</t> imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.
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In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. (C) SPECT/CT imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.

Journal: Biomaterials

Article Title: A 177 Lu-nucleotide Coordination Polymer-incorporated Thermosensitive Hydrogel with Anti-inflammatory and Chondroprotective Capabilities for Osteoarthritis Treatment

doi: 10.1016/j.biomaterials.2025.123098

Figure Lengend Snippet: In vivo retention of 177 Lu/AMP@CG hydrogel post-intraarticular injection. (A) SPECT planar imaging in healthy rats treated with 177 Lu/AMP@CG hydrogel, 177 Lu@CG hydrogel, and free 177 Lu. (B) 177 Lu content in the rat joints after intra-articular injection. (C) SPECT/CT imaging of rats after 177 Lu/AMP@CG hydrogel treatment. (D) Ex vivo biodistribution of radioisotope measured at 16 days post-injection. **P < 0.01, ***P < 0.001.

Article Snippet: Static SPECT scans were conducted at 1 h, 2 d, 4 d, and 16 d post-injection using a SPECT/CT scanner (Precedence 16, Philips, Netherlands).

Techniques: In Vivo, Injection, Single Photon Emission Computed Tomography, Imaging, Ex Vivo

Meta-analysis on the detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at staging. Meta-analysis was performed using a random-effects model. Pooled values were presented along with corresponding 95% confidence intervals (95% CI) values. The size of the squares indicates the weight of each study.

Journal: Frontiers in Medicine

Article Title: Detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in prostate cancer: a systematic review and a meta-analysis

doi: 10.3389/fmed.2026.1827510

Figure Lengend Snippet: Meta-analysis on the detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at staging. Meta-analysis was performed using a random-effects model. Pooled values were presented along with corresponding 95% confidence intervals (95% CI) values. The size of the squares indicates the weight of each study.

Article Snippet: Schmidkonz et al. ( ) , 99m Tc–MIP-1404 , Symbia T2 or T6 SPECT/CT system (Siemens Healthcare, Hoffman Estates, IL) , nr , nr , Total body scintigraphy + SPECT/CT thorax, abdomen and pelvis , Histological and CT.

Techniques: Single Photon Emission Computed Tomography

Funnel plot for the evaluation for bias assessment of studies concerning [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at staging.

Journal: Frontiers in Medicine

Article Title: Detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in prostate cancer: a systematic review and a meta-analysis

doi: 10.3389/fmed.2026.1827510

Figure Lengend Snippet: Funnel plot for the evaluation for bias assessment of studies concerning [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at staging.

Article Snippet: Schmidkonz et al. ( ) , 99m Tc–MIP-1404 , Symbia T2 or T6 SPECT/CT system (Siemens Healthcare, Hoffman Estates, IL) , nr , nr , Total body scintigraphy + SPECT/CT thorax, abdomen and pelvis , Histological and CT.

Techniques: Single Photon Emission Computed Tomography

Meta-analysis on the detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at biochemical recurrence. Meta-analysis was performed using a random-effects model. Pooled values were presented along with corresponding 95% confidence intervals (95% CI) values. The size of the squares indicates the weight of each study.

Journal: Frontiers in Medicine

Article Title: Detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in prostate cancer: a systematic review and a meta-analysis

doi: 10.3389/fmed.2026.1827510

Figure Lengend Snippet: Meta-analysis on the detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at biochemical recurrence. Meta-analysis was performed using a random-effects model. Pooled values were presented along with corresponding 95% confidence intervals (95% CI) values. The size of the squares indicates the weight of each study.

Article Snippet: Schmidkonz et al. ( ) , 99m Tc–MIP-1404 , Symbia T2 or T6 SPECT/CT system (Siemens Healthcare, Hoffman Estates, IL) , nr , nr , Total body scintigraphy + SPECT/CT thorax, abdomen and pelvis , Histological and CT.

Techniques: Single Photon Emission Computed Tomography

Funnel plot for the evaluation for bias assessment of studied concerning [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at biochemical recurrence.

Journal: Frontiers in Medicine

Article Title: Detection rate of [ 99m Tc]Tc-PSMA SPECT/CT in prostate cancer: a systematic review and a meta-analysis

doi: 10.3389/fmed.2026.1827510

Figure Lengend Snippet: Funnel plot for the evaluation for bias assessment of studied concerning [ 99m Tc]Tc-PSMA SPECT/CT in patients with PCa at biochemical recurrence.

Article Snippet: Schmidkonz et al. ( ) , 99m Tc–MIP-1404 , Symbia T2 or T6 SPECT/CT system (Siemens Healthcare, Hoffman Estates, IL) , nr , nr , Total body scintigraphy + SPECT/CT thorax, abdomen and pelvis , Histological and CT.

Techniques: Single Photon Emission Computed Tomography